The present study as designed to formulate and develop 12 prototype gastro retentive mucoadhesive tablets formulations using alfuzosin HCl as a model drug. Alfuzosin HCl belongs to a series of drugs called alpha blockers used in the treatment of benign prostrate hyperplasia. Based on the preformulation studies 12 optimized formulations were prepared by direct compression using a swelling agent viz: carbopol 934P and controlled release polymers such as HPMCK15M, HPMCK4M, sodium carboxyl methyl cellulose and sodium alginate in different concentration. A dissolution method and an analytical procedure by UV spectrophotometry were developed and validated for evaluation of the dissolution behavior of designed tablet dosage form. The method was validated according to international conference on harmonization (ICH) guidelines which include accuracy, precision, specificity, linearity and analytical range. The tablets were also evaluated for other quality parameters like in-vitro diffusion study and in-vitro bioadhesion strength. The data obtained from dissolution studies was fitted in 5 models viz: zero order, first order, higuchi matrix, peppas and erosion plot. Mathematical analysis of the release kinetics indicated that the nature of drug release from the matrix tablets was dependent on drug diffusion and polymer relaxation and therefore followed non-fickian or anomalous release approaching zero order kinetics. The cumulative percentage drug release data revealed that formulations and were highly effective in retarding drug release up to 15 hrs respectively as compared to marketed preparation releasing the drug at the end of 10th hr itself.
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